|   別稱

IL1-B; IL1-Beta; IL1F2; IL-1β; Interleukin-1 Family Member 2; Catabolin

|   IL-1β 簡介

白細(xì)胞介素1β（IL-1β）是一種在各種細(xì)胞中產(chǎn)生的促炎癥細(xì)胞因子，包括單核細(xì)胞、組織巨噬細(xì)胞、角質(zhì)細(xì)胞和其他上皮細(xì)胞。IL-1α和IL-1β都與相同的受體結(jié)合，并具有類似甚至相同的生物學(xué)特性。這些細(xì)胞因子具有廣泛的活性，包括通過誘導(dǎo)IL-2的釋放刺激胸腺細(xì)胞的增殖，B細(xì)胞的成熟和增殖，有絲分裂的FGF樣活性和刺激滑膜細(xì)胞釋放前列腺素和膠原酶的能力。然而，IL-1β是一種分泌型的細(xì)胞因子，而IL-1α主要是一種細(xì)胞相關(guān)的細(xì)胞因子。

|   特異性

可檢測樣本中人的IL-1β，且與其類似物無明顯交叉反應(yīng)。

|   典型數(shù)據(jù)及參考曲線

由于實驗操作條件的不同（ 如操作者、移液技術(shù)、洗板技術(shù)和穩(wěn)定條件等），標(biāo)準(zhǔn)曲線的OD值會有所差異。以下數(shù)據(jù)和曲線僅供參考，實驗者需根據(jù)自己的實驗建立標(biāo)準(zhǔn)曲線。

注意：本圖僅供參考，應(yīng)以同次試驗標(biāo)準(zhǔn)品所繪標(biāo)準(zhǔn)曲線計算標(biāo)本含量。

|   重復(fù)性

板內(nèi)變異系數(shù)小于10%，板間變異系數(shù)小于10%

|   回收率

在選取的健康人血清、血漿、細(xì)胞培養(yǎng)上清中加入3個不同濃度水平的人IL-1β，計算回收率

|   線性稀釋

分別在選取的4份健康人血清、血漿、細(xì)胞培養(yǎng)上清中加入高濃度人IL-1β，在標(biāo)準(zhǔn)曲線動力學(xué)范圍內(nèi)進(jìn)行稀釋，評估線性。

注：ELISA試劑盒檢測范圍等數(shù)據(jù)，因檢測樣本 的不同而調(diào)整，實際數(shù)據(jù)以隨貨說明書為準(zhǔn)。

|   ELISA操作視頻

|   ELISA操作前必讀 / 下載

|   客戶發(fā)表的文獻(xiàn)

Interaction with CD68 and regulation of GAS6 expression by endosialin in fibroblasts drives recruitment and polarization of macrophages in hepatocellular carcinoma

Rank: IF 11.2

Journal: Cancer Research

Year: 2020

DOI: 10.1158/0008-5472.CAN-19-2691

5-Bromo-3,4-dihydroxybenzaldehyde attenuates endothelial cells injury from high glucose-induced damage

Rank: IF 7.5

Journal: Biomedicine & Pharmacotherapy

Year: 2022

DOI: 10.1016/j.biopha.2022.113793

The Effect of Allograft Inflammatory Factor-1 on Inflammation, Oxidative Stress, and Autophagy via miR-34a/ATG4B Pathway in Diabetic Kidney Disease

Rank: IF 7.31

Journal: Oxidative Medicine and Cellular Longevity

Year: 2022

DOI: 10.1155/2022/1668000

Synthesis and pharmacological validation of fluorescent diarylsulfonylurea analogues as NLRP3 inhibitors and imaging probes

Rank: IF 6.7

Journal: European Journal of Medicinal Chemistry

Year: 2022

DOI: 10.1016/j.ejmech.2022.114338

Pyroptosis is involved in the inhibitory effect of FL118 on growth and metastasis in colorectal cancer

Rank: IF 6.1

Journal: Life Sciences

Year: 2020

DOI: 10.1016/j.lfs.2020.118065

The expression of parthanatos markers and miR-7 mimic protects photoreceptors from parthanatos by repressing α-synuclein in retinal detachment

Rank: IF 6

Journal: American Journal of Pathology

Year: 2023

DOI: 10.1016/j.ajpath.2023.06.011

Anti-Inflammatory Effect of Geniposide on Regulating the Functions of Rheumatoid Arthritis Synovial Fibroblasts via Inhibiting Sphingosine-1-Phosphate Receptors1/3 Coupling Gαi/Gαs Conversion

Rank: IF 5.6

Journal: Frontiers in Pharmacology

Year: 2020

DOI: 10.3389/fphar.2020.584176

The rCC16 Protein Protects Against LPS-Induced Cell Apoptosis and Inflammatory Responses in Human Lung Pneumocytes

Rank: IF 5.6

Journal: Frontiers in Pharmacology

Year: 2020

DOI: 10.3389/fphar.2020.01060

PINK1-Dependent Mitophagy Reduced Endothelial Hyperpermeability and Cell Migration Capacity Under Simulated Microgravity

Rank: IF 5.5

Journal: Frontiers in Cell and Developmental Biology

Year: 2022

DOI: 10.3389/fcell.2022.896014

Anti?β₂GPI/β₂GPI induces neutrophil pyroptosis and thereby enhances ICAM?1 and IL?8 expression in endothelial cells

Rank: IF 5.4

Journal: International Journal of Molecular Medicine

Year: 2022

DOI: 10.3892/ijmm.2022.5120