|   別稱

IGIF; IL-1g; IL1F4; IL1-F4; Interferon-Gamma-Inducing Factor; Interleukin-1 Family Member 4; Iboctadekin; Interleukin-1 Gamma

|   IL-18 簡介

白細胞介素18（IL-18，又稱干擾素-γ誘導(dǎo)因子）是一種蛋白質(zhì)，由IL18基因編碼。該基因編碼的蛋白質(zhì)是一種促炎癥細胞因子。許多細胞類型，包括造血細胞和非造血細胞，都有可能產(chǎn)生IL-18。最初，IL-18的產(chǎn)生是在Kupffer細胞、肝臟駐留的巨噬細胞中被認可。然而，IL-18在非造血細胞，如腸道上皮細胞、角質(zhì)細胞和內(nèi)皮細胞中也有構(gòu)成性表達，它可調(diào)節(jié)先天性和適應(yīng)性免疫，其失調(diào)可引起自身免疫性或炎癥性疾病。

|   特異性

可檢測樣本中人的IL-18，且與其類似物無明顯交叉反應(yīng)。

|   典型數(shù)據(jù)及參考曲線

由于實驗操作條件的不同（ 如操作者、移液技術(shù)、洗板技術(shù)和穩(wěn)定條件等），標準曲線的OD值會有所差異。以下數(shù)據(jù)和曲線僅供參考，實驗者需根據(jù)自己的實驗建立標準曲線。

注意：本圖僅供參考，應(yīng)以同次試驗標準品所繪標準曲線計算標本含量。

|   重復(fù)性

板內(nèi)變異系數(shù)小于10%，板間變異系數(shù)小于10%

|   回收率

在選取的健康人血清、血漿、細胞培養(yǎng)上清中加入3個不同濃度水平的人IL-18，計算回收率

|   線性稀釋

分別在選取的4份健康人血清、血漿、細胞培養(yǎng)上清中加入高濃度人IL-18，在標準曲線動力學(xué)范圍內(nèi)進行稀釋，評估線性。

注：ELISA試劑盒檢測范圍等數(shù)據(jù)，因檢測樣本 的不同而調(diào)整，實際數(shù)據(jù)以隨貨說明書為準。

|   ELISA操作視頻

|   ELISA操作前必讀 / 下載

|   客戶發(fā)表的文獻

Breaking-down Tumoral Physical Barrier by Remotely Unwrapping Metal-Polyphenol-Packaged Hyaluronidase for Optimizing Photothermal/Photodynamic Therapy-Induced Immune Response

Rank: IF 27.4

Journal: Advanced Materials

Year: 2024

DOI: 10.1002/adma.202310673

The circular RNA circINPP4B acts as a sponge of miR-30a to regulate Th17 cell differentiation during progression of experimental autoimmune encephalomyelitis

Rank: IF 21.8

Journal: Cellular & Molecular Immunology

Year: 2021

DOI: 10.1038/s41423-021-00748-y

Parabacteroides distasonis uses dietary inulin to suppress NASH via its metabolite pentadecanoic acid

Rank: IF 20.5

Journal: Nature Microbiology

Year: 2023

DOI: 10.1038/s41564-023-01418-7

An emerging antibacterial nanovaccine for enhanced chemotherapy by selec‐tively eliminating tumor-colonizing bacteria

Rank: IF 18.8

Journal: Science Bulletin

Year: 2024

DOI: 10.1016/j.scib.2024.06.016

A Polysaccharide Metal Phenolic Network Nanocomposite for Theranostic Applications in Inflammatory Bowel Disease

Rank: IF 18.5

Journal: Advanced Functional Materials

Year: 2024

DOI: 10.1002/adfm.202416918

Oral Nano-antioxidants Improve Sleep by Restoring Intestinal Barrier Integrity and Preventing Systemic Inflammation

Rank: IF 16.3

Journal: National Science Review

Year: 2023

DOI: 10.1093/nsr/nwad309

Gastrointestinal MicroenvironmentResponsive Nanoencapsulation of Probioticsand Drugs for Synergistic Therapy ofIntestinal Diseases

Rank: IF 15.8

Journal: ACS Nano

Year: 2023

DOI: 10.1021/acsnano.3c02646

Neutrophil-Mimetic Upconversion Photosynthetic Nanosystem Derived from Microalgae for Targeted Treatment of Thromboembolic Stroke

Rank: IF 15.8

Journal: ACS Nano

Year: 2024

DOI: 10.1021/acsnano.4c06247

Novel compound FLZ alleviates rotenone-induced PD mouse model by suppressing TLR4/MyD88/NF-κB pathway through microbiota–gut–brain axis

Rank: IF 14.7

Journal: Acta Pharmaceutica Sinica B

Year: 2021

DOI: 10.1016/j.apsb.2021.03.020

Enrichment and sensing tumor cells by embedded immunomodulatory DNA hydrogel to inhibit postoperative tumor recurrence

Rank: IF 14.7

Journal: Nature Communications

Year: 2023

DOI: 10.1038/s41467-023-40085-4