|   別稱

Corticosrone

|   CORT 簡介

皮質(zhì)酮，又稱 17-脫氧皮質(zhì)醇和 11β,21-二羥基黃體酮，是一種 21 碳的皮質(zhì)類固醇激素，在腎上腺皮質(zhì)中產(chǎn)生。除了 17α-羥化酶缺乏導(dǎo)致的非常罕見的 先天性腎上腺增生癥外，它對人類的重要性不大。在許多物種中，包括兩棲 動物、爬行動物、嚙齒動物和鳥類，皮質(zhì)酮是一種主要的糖皮質(zhì)激素，參與 調(diào)節(jié)能量、免疫反應(yīng)和壓力反應(yīng)。皮質(zhì)酮通過醛固酮合成酶轉(zhuǎn)化為醛固酮， 醛固酮合成酶僅在腎小球細(xì)胞的線粒體中發(fā)現(xiàn)。腎小球細(xì)胞存在于腎小球區(qū)， 它是腎上腺皮質(zhì)內(nèi)分泌細(xì)胞的最表層區(qū)域。皮質(zhì)酮是礦物皮質(zhì)激素醛固酮的前體分子，是體內(nèi)鈉和鉀水平的主要平衡調(diào)節(jié)劑之一。

|   特異性

可檢測樣本中大鼠的CORT，且與其類似物無明顯交叉反應(yīng)。

|   典型數(shù)據(jù)及參考曲線

由于實驗操作條件的不同（ 如操作者、移液技術(shù)、洗板技術(shù)和穩(wěn)定條件等），標(biāo)準(zhǔn)曲線的OD值會有所差異。以下數(shù)據(jù)和曲線僅供參考，實驗者需根據(jù)自己的實驗建立標(biāo)準(zhǔn)曲線。

|   重復(fù)性

板內(nèi)變異系數(shù)小于10%，板間變異系數(shù)小于10%

|   回收率

在選取的健康大鼠血清、血漿和中加入3個不同濃度水平的大鼠CORT，計算回收率

|   線性稀釋

分別在選取的4份健康大鼠血清、血漿和中加入高濃度大鼠CORT，在標(biāo)準(zhǔn)曲線動力學(xué)范圍內(nèi)進(jìn)行稀釋，評估線性。

注：ELISA試劑盒檢測范圍等數(shù)據(jù)，因檢測樣本 的不同而調(diào)整，實際數(shù)據(jù)以隨貨說明書為準(zhǔn)。

|   客戶發(fā)表的文獻(xiàn)

Icariin ameliorates learning and memory impairments through ERK/CaMKIIα/CREB signaling and HPA axis in prenatally stressed female offspring

Rank: IF 6.9

Journal: Biomedicine & Pharmacotherapy

Year: 2019

DOI: 10.1016/j.biopha.2019.109077

Imperatorin ameliorates learning and memory deficits through BDNF/TrkB and ERK/CaMKIIα/CREB signaling in prenatally-stressed female offspring

Rank: IF 6.1

Journal: Phytotherapy Research

Year: 2020

DOI: 10.1002/ptr.6692

Ferulic Acid Improves Depressive-Like Behavior in Prenatally-Stressed Offspring Rats via Anti-Inflammatory Activity and HPA Axis

Rank: IF 4.9

Journal: International Journal of Molecular Sciences

Year: 2019

DOI: 10.3390/ijms20030493

Tetrandrine inhibits aldosterone synthesis by covalently targeting CYP11A1 to attenuate hypertension

Rank: IF 4.4

Journal: Frontiers in Pharmacology

Year: 2024

DOI: 10.3389/fphar.2024.1387756

Effects of cannabidiol on AMPKα2 /HIF-1α/BNIP3/NIX signaling pathway in skeletal muscle injury

Rank: IF 4.4

Journal: Frontiers in Pharmacology

Year: 2024

DOI: 10.3389/fphar.2024.1450513

Camellia nitidissima Chi extract promotes adult hippocampal neurogenesis and attenuates chronic corticosterone-induced depressive behaviours through regulating Akt/GSK3β/CREB signaling pathway

Rank: IF 3.8

Journal: Journal of Functional Foods

Year: 2022

DOI: 10.1016/j.jff.2022.105199

Beneficial effects of Dendrobium nobile Lindl. alkaloids (DNLA) on anxiety and depression induced by chronic unpredictable stress in rats.

Rank: IF 2.7

Journal: Brain Research

Year: 2021

DOI: 10.1016/j.brainres.2021.147647

Dose Optimization of Anxiolytic Compounds Group in Valeriana jatamansi Jones and Mechanism Exploration by Integrating Network Pharmacology and Metabolomics Analysis.

Rank: IF 2.7

Journal: Brain Sciences

Year: 2022

DOI: 10.3390/brainsci12050589

Electroacupuncture ameliorates cardiac dysfunction in myocardial ischemia model rats: a potential role of the hypothalamic-pituitary-adrenal axis

Rank: IF 2

Journal: Journal of Traditional Chinese Medicine

Year: 2023

DOI: 10.19852/j.cnki.jtcm.20230727.001

Seasonal photoperiodic influence of pineal melatonin on hypothalamic-pituitary-adrenal axis-hippocampal-receptor in male rats

Rank: IF 0.7

Journal: Journal of Traditional Chinese Medical Sciences

Year: 2022

DOI: 10.1016/j.jtcms.2022.03.005